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KMID : 0616120210520040203
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Korean Journal of Pharmacognosy
2021 Volume.52 No. 4 p.203 ~ p.207
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Structure and Bioactivity of Boholamide A from a Tidal Mudflat Actinomycete
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Seo Jeong-Won
Moon Kyu-Ho
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Abstract
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LC/MS approach targeting secondary metabolites of bacterial strain resulted in the discovery of boholamide A (1), from the culture of marine actinomycete strain which was isolated from a tidal mudflat in Muan, Republic of Korea. Boholamide A (1), a cyclodepsipeptide with HDMN, APD, glycine, and valine was structurally determined by using 1D/2D NMR spectroscopy, mass spectrometry and UV spectroscopy. Boholamide A (1) showed the inhibitory activity against Bacillus subtilis, with IC50 value of 0.08 mM.
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KEYWORD
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Bacterial secondary metabolite, Structural determination, Boholamide A, Cyclodepsipeptide, Tidal mudflat
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